AU Comment: HIV-2 Infection in Australia HIV-2 is uncommon in Australia. Diagnosis of HIV-2 in Australia can be difficult because of the cross-reaction of serological tests with HIV-1 proteins. St Vincent’s Hospital, Sydney, and the Victorian Infectious Diseases Reference Laboratory (VIDRL) offers an HIV-2 western blot confirming HIV-2 infection by reactivity to specific HIV-2 glycoproteins. …
AU Comment: Adolescents and young adults with HIV in Australia In 2021, 4/745 (0.5%) of all new HIV notifications in Australia were among individuals aged 19 years or younger, with the majority (3/4) of these notifications among those aged 15-19 years. Reference: King J, McManus H, Kwon A, Gray A, McGregor S. HIV, viral hepatitis …
AU Comment: Diagnosis of early HIV infection in Australia When acute HIV-1 infection is suspected, and an anti-HIV antibody and/or antibody/antigen combo test is negative or the western blot is indeterminate, other suitable test options include a nucleic acid test for HIV. However, proviral DNA tests are not widely available in Australia and HIV viral …
This section has information on Special Patient Populations. Please click on the below links or follow the table of contents to access the information you are looking for. Women with HIV Substance Use Disorders and HIV HIV-2 Infection Early (Acute and Recent) HIV Infection Transgender People with HIV HIV and the Older Person Adolescents and …
AU Comment: Ibalizumab (IBA) Ibalizumab (IBA) a monoclonal antibody that is NOT PBS listed in Australia. Discontinuation or interruption of antiretroviral therapy (ART) may result in viral rebound, immune decompensation, and/or clinical progression.1-5 Thus, discontinuation or planned interruption of ART is not recommended outside the context of a clinical trial (AI). However, unplanned interruption of ART may …
Panel’s Recommendations for Optimizing Antiretroviral Therapy in the Setting of Virologic Suppression Key Considerations and Panel’s Recommendations A long-acting ARV regimen of injectable cabotegravir (CAB) and rilpivirine (RPV) given every 1 or 2 months is an optimization option for patients who are engaged with their health care, virologically suppressed on oral therapy for 3 to …
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AU Comment: Poor CD4 cell recovery and persistent inflammation despite viral suppression Current DHHS recommendations are suitable for implementation in Australia, including the following points: In individuals with viral suppression, adding ARV drugs or switching ARV drug classes does not consistently improve CD4 cell recovery or reduce all relevant markers of immune activation and is not …
AU Comment: Australian Special Access Scheme for ARV treatments In heavily treatment-experienced patients, where treatment options are limited by drug resistance, toxicities or other issues, enrolment in a clinical trial of a new antiretroviral agent (if available), or use of an agent not yet TGA-approved for marketing but available through the Special Access Scheme, can …
This section has information on Management of the Treatment-Experienced Patient. Please click on the below links or follow the table of contents to access the information you are looking for. Virologic Failure Optimizing ART in the Setting of Virologic Suppression Poor CD4 Cell Recovery Discontinuation or Interruption of ARV
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