The DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents (a working group of the Office of AIDS Research Advisory Council) has reviewed and updated the text and references of previous versions of the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. The Sub-Committee for Guidance on HIV Management in Australia has reviewed these updates and provided updated Australian commentary in July 2023. Key updates are summarized below.